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Fig. 1 · Structure
Cat. No.
A11967
CAS No.
438190-29-5
Formula
C11H6F3NO2S
Mol. Weight
273.23

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TCS PIM-1 4a (SMI-4a)

Cat. No. A11967 CAS 438190-29-5

Pim inhibitor

TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively).

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Biological Activity

Target & Activity

Target Activity Value
Pim1 17 nM

Cellular Effect

Cell Line Activity Value Description Reference
DLD-1 IC50 17.8 μM Inhibition of growth of DLD-1 cell line after 96 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
DLD-1 IC50 31.4 μM Inhibition of growth of DLD-1 cell line after 72+72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
DLD-1 IC50 37.4 μM Inhibition of growth of DLD-1 cell line after 72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
DLD-1 IC50 40.1 μM Inhibition of growth of DLD-1 cell line after 24+72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HCT-116 IC50 36.8 μM Inhibition of growth of HCT116 cell line after 72+72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HCT-116 IC50 45.5 μM Inhibition of growth of HCT116 cell line after 96 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HCT-116 IC50 48.8 μM Inhibition of growth of HCT116 cell line after 72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HCT-116 IC50 91.7 μM Inhibition of growth of HCT116 cell line after 24+72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HCT-8 IC50 100 μM Inhibition of growth of HCT-8 cell line after 72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HCT-8 IC50 82.2 μM Inhibition of growth of HCT-8 cell line after 96 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HL-60 GI50 4.9 μM Antiproliferative activity against human HL-60 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay [PMID: 34958208]
HT-29 IC50 31.4 μM Inhibition of growth of HT-29 cell line after 72+72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HT-29 IC50 38.8 μM Inhibition of growth of HT-29 cell line after 72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HT-29 IC50 59.7 μM Inhibition of growth of HT-29 cell line after 96 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
HT-29 IC50 71.7 μM Inhibition of growth of HT-29 cell line after 24+72 hours of exposure time with the compound dissolved in DMSO [PMID: 15993594]
MOLM-13 GI50 2.16 μM Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay [PMID: 34958208]
Mononuclear cell line GI50 8.35 μM Antiproliferative activity against AML patient derived mononuclear cells of assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay [PMID: 34958208]
PC-3 IC50 17 μM Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay [PMID: 19072652]

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 438190-29-5
Applications Pim inhibitor
Formula C11H6F3NO2S
Molecular Weight 273.23
Synonyms SMI-4a
SMILES
O=C(NC/1=O)SC1=C\C2=CC=CC(C(F)(F)F)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 47 mg/mL (172.01 mM)
Water Insoluble
Ethanol 28 mg/mL (102.47 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

In Vivo Preparation

Concentration
28 mg/mL
Vehicle
30% PEG400+0.5% Tween80+5% propylene glycol

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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