SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
Product Information
Catalog Num
A11945
Formula
C11H6F3NO2S
Molecular Weight
273.2
CAS Number
327033-36-3
SMILES
O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2
Synonyms
SMI4a
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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