(Z)-SMI-4a

Catalog No.: A11945

Pim Inhibitor

(Z)-SMI-4a

(Z)-SMI-4a Chemical Structure

CAS NO. 327033-36-3

SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.

Availability: In stock

Package Price Qty
10 mg
$65.00
25 mg
$140.00
50 mg
$260.00
100 mg
$500.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Liong S, .et al. Placental Pim-1 expression is increased in obesity and regulates cytokine- and toll-like receptor-mediated inflammation, Placenta, 2017, May;53:101-112 PMID: 28487013

Biological Activity

SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.6 mL 183.02 mL 366.03 mL
0.5 mM 7.32 mL 36.6 mL 73.21 mL
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL

*The above data is based on the productmolecular weight 273.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11945
Actions Inhibitor
M. Wt 273.2
Formula C11H6F3NO2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 327033-36-3
Synonyms SMI4a
SMILES O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2

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