(2S,3R)-LP99 is a highly selective inhibitor of BRD7 and BRD9, exhibiting a KD of 99 nM for BRD9. This compound effectively disrupts the binding of BRD7 and BRD9 to acetylated histones both in vitro and in cellular environments. (2S,3R)-LP99 is instrumental for research into the regulatory roles of BRD7 and BRD9 in pro-inflammatory cytokine secretion, making it a valuable tool for studies investigating inflammation and epigenetic regulation.
(2S,3R)-LP99 is a highly selective inhibitor of BRD7 and BRD9, exhibiting a KD of 99 nM for BRD9. This compound effectively disrupts the binding of BRD7 and BRD9 to acetylated histones both in vitro and in cellular environments. (2S,3R)-LP99 is instrumental for research into the regulatory roles of BRD7 and BRD9 in pro-inflammatory cytokine secretion, making it a valuable tool for studies investigating inflammation and epigenetic regulation.
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