Fig. 1 · Structure
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4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium
Fluorogenic Substrate
4-Methylumbelliferyl-α-L-iduronide 2-sulfate sodium is a fluorogenic substrate specifically for iduronate-2-sulfatase (I2S). Upon hydrolysis by the lysosomal enzyme α-L-iduronidase (IDUA), it releases the fluorophore 4-Methylumbelliferone, allowing for sensitive detection of enzymatic activity. This reagent is particularly useful in research focused on lysosomal storage disorders, including Hurler syndrome, facilitating the assessment of enzyme function and disease progression.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2181774-46-7 |
| Applications | Fluorogenic Substrate |
| Formula | C16H14Na2O12S |
| Molecular Weight | 476.32 |
| Synonyms | 4-MU-α-idoa 2-sulfate sodium |
| SMILES | O=S(O[C@H]([C@H]([C@@H]([C@@H](O1)C(O[Na])=O)O)O)[C@@H]1OC2=CC=C(C(C)=CC(O3)=O)C3=C2)(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.