4-N3Pfp-NHS ester is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), targeting the conjugation of therapeutic agents to antibodies. This compound features an azide group, enabling click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its robust reactivity makes it an essential tool for enhancing the efficacy and selectivity of ADCs in cancer research and therapeutic development.
4-N3Pfp-NHS ester is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), targeting the conjugation of therapeutic agents to antibodies. This compound features an azide group, enabling click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its robust reactivity makes it an essential tool for enhancing the efficacy and selectivity of ADCs in cancer research and therapeutic development.
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