Fig. 1 · Structure
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6-Maleimidocaproic acid sulfo-NHS sodium
PROTAC Linkers
6-Maleimidocaproic acid sulfo-NHS sodium is a sulfonated linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to ubiquitin ligases, promoting targeted degradation of specific proteins within cellular systems. Its unique structure enhances solubility and stability, making it suitable for various applications in drug discovery and development focused on protein modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 215312-86-0 |
| Applications | PROTAC Linkers |
| Formula | C14H15N2NaO9S |
| Molecular Weight | 410.33 |
| Synonyms | Sulfo-EMCS |
| SMILES | O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCCN2C(C=CC2=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.