Fig. 1 · Structure
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6-Maleimidocaproic acid sulfo-NHS
PROTAC Linkers
6-Maleimidocaproic acid sulfo-NHS is a sulfonated linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound serves as an effective tool for covalent conjugation to target proteins, facilitating the development of bifunctional molecules that promote the ubiquitin-proteasome pathway. Its stability and reactivity make it suitable for applications in chemical biology and targeted protein degradation research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 103848-61-9 |
| Applications | PROTAC Linkers |
| Formula | C14H16N2O9S |
| Molecular Weight | 388.35 |
| Synonyms | Sulfo-EMCS free acid |
| SMILES | O=C(ON1C(C(S(=O)(O)=O)CC1=O)=O)CCCCCN2C(C=CC2=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.