8,11,14-Eicosatriynoic Acid functions as a biochemical assay reagent primarily targeting the inhibition of prostaglandin and leukotriene biosynthesis. It effectively inhibits human 12-lipoxygenase (12-LO), cyclooxygenase (COX), and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μM, and 25 μM, respectively. This compound also demonstrates inhibition of slow-reacting substances involved in allergic reactions, with an IC50 of 10 μM. Beyond its role in modulating inflammatory pathways, 8,11,14-Eicosatriynoic Acid serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition. Its multifaceted applications are valuable in exploring disease mechanisms, particularly in cancer and oxidative stress conditions.
8,11,14-Eicosatriynoic Acid functions as a biochemical assay reagent primarily targeting the inhibition of prostaglandin and leukotriene biosynthesis. It effectively inhibits human 12-lipoxygenase (12-LO), cyclooxygenase (COX), and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μM, and 25 μM, respectively. This compound also demonstrates inhibition of slow-reacting substances involved in allergic reactions, with an IC50 of 10 μM. Beyond its role in modulating inflammatory pathways, 8,11,14-Eicosatriynoic Acid serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition. Its multifaceted applications are valuable in exploring disease mechanisms, particularly in cancer and oxidative stress conditions.
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