9-Methylstreptimidone is a microbial metabolite primarily derived from Streptomyces sp. S-885, exhibiting notable antifungal and antiviral properties. It demonstrates activity against various fungal species, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus, with minimum inhibitory concentrations (MICs) ranging from 4 to 20 μg/mL. Additionally, 9-Methylstreptimidone has effective antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). In vivo studies indicate that this compound enhances survival in mouse models challenged with influenza A2 (H2N2) and C. albicans when administered prior to infection.
9-Methylstreptimidone is a microbial metabolite primarily derived from Streptomyces sp. S-885, exhibiting notable antifungal and antiviral properties. It demonstrates activity against various fungal species, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus, with minimum inhibitory concentrations (MICs) ranging from 4 to 20 μg/mL. Additionally, 9-Methylstreptimidone has effective antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). In vivo studies indicate that this compound enhances survival in mouse models challenged with influenza A2 (H2N2) and C. albicans when administered prior to infection.
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