Fig. 1 · Structure
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α-Hydroxyglutaric acid
Cat. No.
A29322
CAS
2889-31-8
Endogenous Metabolite
α-Hydroxyglutaric acid is an endogenous metabolite that acts as a competitive inhibitor of various α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET enzyme family responsible for converting 5-methylcytosine (5mC) to hydroxymethylcytosine (5hmC). This compound is instrumental in epigenetic research, influencing histone modification and DNA methylation processes. Its role in metabolic pathways also makes it valuable for studying glioma metabolism and hypoxia-related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2889-31-8 |
| Applications | Endogenous Metabolite |
| Formula | C5H8O5 |
| Molecular Weight | 148.11 |
| Synonyms | 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid |
| SMILES | O=C(O)C(O)CCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.