α2A-AR agonist 1 is a selective agonist that targets the α2-adrenergic receptor (α2A-AR) with an EC50 of 0.23 nM. This compound demonstrates a significant hypnotic effect, as evidenced by an ED50 of 0.138 mg/kg in loss of righting reflex (LORR) studies. Notably, α2A-AR agonist 1 also shows metabolic stability in mouse liver microsomes, making it a valuable tool for research in pharmacology and neurobiology.
α2A-AR agonist 1 is a selective agonist that targets the α2-adrenergic receptor (α2A-AR) with an EC50 of 0.23 nM. This compound demonstrates a significant hypnotic effect, as evidenced by an ED50 of 0.138 mg/kg in loss of righting reflex (LORR) studies. Notably, α2A-AR agonist 1 also shows metabolic stability in mouse liver microsomes, making it a valuable tool for research in pharmacology and neurobiology.
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