L-771688

Catalog No.: A58290
Adrenergic Receptor Antagonist
L-771688 is a highly selective antagonist of the α1A-Adrenoceptor, exhibiting a Ki of 0.43±0.02 nM. This compound demonstrates potent inhibition of α1A-mediated responses, making it valuable for investigating adrenergic signaling pathways. It is useful in research applications focused on cardiovascular physiology and pharmacology, as well as studies aimed at understanding the role of α1A receptors in various pathological conditions.
Grouped product items
Size Price Stock Qty
1mg
$315.00
In stock
5mg
$810.00
In stock
10mg
$1,615.00
In stock
25mg
$3,225.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionL-771688 is a highly selective antagonist of the α1A-Adrenoceptor, exhibiting a Ki of 0.43±0.02 nM. This compound demonstrates potent inhibition of α1A-mediated responses, making it valuable for investigating adrenergic signaling pathways. It is useful in research applications focused on cardiovascular physiology and pharmacology, as well as studies aimed at understanding the role of α1A receptors in various pathological conditions.
Product Information
Catalog NumA58290
FormulaC28H33F2N5O5
Molecular Weight557.59
CAS Number200050-59-5
SMILESO=C(C([C@H](C1=CC=C(F)C(F)=C1)N2C(NCCCN3CCC(C4=NC=CC=C4)CC3)=O)=C(COC)NC2=O)OC
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2