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ABT-737-d8

Catalog No.: A92340
Stable Isotope
ABT-737-d8 is a deuterium-labeled BH3 mimetic that targets Bcl-2, Bcl-xL, and Bcl-w with EC50 values of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. This reagent disrupts the BCL-2/BAX complex and activates the intrinsic apoptotic pathway in a BAK-dependent, BIM-independent manner. ABT-737-d8 promotes autophagy and is valuable for research in acute myeloid leukemia (AML) and related apoptosis studies.
ABT-737-d8 1217686-68-4 Stable Isotope
Grouped product items
Size Price Stock Qty
100µg
$115.00
In stock
1mg
$590.00
In stock
5mg
$1,515.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionABT-737-d8 is a deuterium-labeled BH3 mimetic that targets Bcl-2, Bcl-xL, and Bcl-w with EC50 values of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. This reagent disrupts the BCL-2/BAX complex and activates the intrinsic apoptotic pathway in a BAK-dependent, BIM-independent manner. ABT-737-d8 promotes autophagy and is valuable for research in acute myeloid leukemia (AML) and related apoptosis studies.
Product Information
Catalog NumA92340
FormulaC42H37D8ClN6O5S2
Molecular Weight821.48
CAS Number1217686-68-4
SMILESClC(C=C1)=CC=C1C(C=CC=C2)=C2CN3C([2H])([2H])C([2H])([2H])N(C4=CC=C(C=C4)C(NS(=O)(C5=CC([N+]([O-])=O)=C(C=C5)N[C@H](CCN(C)C)CSC6=CC=CC=C6)=O)=O)C([2H])([2H])C3([2H])[2H]
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Isotope-Labeled Compounds