Acetaminophen-d7 is a deuterium-labeled form of acetaminophen, functioning primarily as a selective inhibitor of cyclooxygenase-2 (COX-2), with an IC50 of 25.8 μM. This stable isotope variant is utilized in pharmacokinetic studies to trace the metabolic pathways of acetaminophen while minimizing interference from natural acetaminophen. Its applications include investigations into analgesic and antipyretic effects, as well as studies on hepatic N-acetyltransferase 2 (NAT2) inhibition.
Acetaminophen-d7 is a deuterium-labeled form of acetaminophen, functioning primarily as a selective inhibitor of cyclooxygenase-2 (COX-2), with an IC50 of 25.8 μM. This stable isotope variant is utilized in pharmacokinetic studies to trace the metabolic pathways of acetaminophen while minimizing interference from natural acetaminophen. Its applications include investigations into analgesic and antipyretic effects, as well as studies on hepatic N-acetyltransferase 2 (NAT2) inhibition.
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