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AcLys-PABC-VC-Aur0101 intermediate-1

Catalog No.: A43255
ADC Linker
AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin-cleavable linker specifically designed for antibody-drug conjugates (ADCs). This compound facilitates targeted drug delivery by ensuring the release of the cytotoxic drug within the tumor microenvironment upon cathepsin-mediated cleavage. It is essential for enhancing the efficacy and specificity of ADCs in cancer therapeutics, providing researchers with a valuable tool for developing novel therapies.
AcLys-PABC-VC-Aur0101 intermediate-1 1609108-48-6 ADC Linker
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin-cleavable linker specifically designed for antibody-drug conjugates (ADCs). This compound facilitates targeted drug delivery by ensuring the release of the cytotoxic drug within the tumor microenvironment upon cathepsin-mediated cleavage. It is essential for enhancing the efficacy and specificity of ADCs in cancer therapeutics, providing researchers with a valuable tool for developing novel therapies.
Product Information
Catalog NumA43255
FormulaC41H53N7O8
Molecular Weight771.90
CAS Number1609108-48-6
SMILESOCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCCCNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > ADC Linker