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AcrB-IN-3

AcrB Efflux Pump Inhibitor

AcrB-IN-3 is a potent inhibitor of the AcrB efflux pump, specifically engineered to enhance the efficacy of various antibiotics. This compound effectively inhibits the efflux of Nile Red, a well-established substrate for AcrB, thereby preventing the pump's function. AcrB-IN-3 has demonstrated a lack of toxicity in nematode models and does not compromise the integrity of the bacterial outer membrane, making it a valuable tool for research into antibiotic resistance mechanisms and efflux pump modulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2890177-94-1
Applications	AcrB Efflux Pump Inhibitor
Formula	C₃₀H₃₃NO₇
Molecular Weight	519.59
SMILES	O=C(C1=CC(OCCCOC2=CC=CC3=C2C=C(C(N4CCOCC4)=O)C5=C3OC(C)(CC5)C)=CC=C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.