Fig. 1 · Structure
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Acriflavine hydrochloride
Antiseptic Agent
Acriflavine hydrochloride is a fluorescent acridine dye that serves as an effective antiseptic agent. Its primary mechanism involves inhibition of HIF-1 by preventing the dimerization of HIF-1α and HIF-1β subunits, as well as blocking the interaction of monocarboxylate transporter 4 (MCT4) with Basigin. This compound has applications in cancer research, particularly in breast cancer, brain tumors, and chronic myeloid leukemia, and it also acts as a potent inhibitor of the papain-like protease (PLpro) involved in SARS-CoV-2 infection.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 69235-50-3 |
| Applications | Antiseptic Agent |
| Formula | C27H27Cl3N6 |
| Molecular Weight | 541.90 |
| Synonyms | Acriflavinium chloride hydrochloride |
| SMILES | C[N+]1=C2C=C(N)C=CC2=CC3=C1C=C(N)C=C3.[H]Cl.NC4=CC=C5C(N=C6C=C(N)C=CC6=C5)=C4.[H]Cl.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.