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ADEP-14

ClpP Activator

ADEP-14 is an activator of the ClpP protease, exhibiting EC50 values of 0.46 μM for Neisseria meningitidis ClpP and 3.67 μM for Escherichia coli ClpP. By binding to the H sites of ClpP, ADEP-14 enhances proteolytic activity, contributing to its antibacterial properties. This compound is valuable for research focused on bacterial infections and the mechanistic studies of protease activation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	1846579-07-4
Applications	ClpP Activator
Formula	C₄₁H₅₄F₂N₆O₈
Molecular Weight	796.90
SMILES	[H][C@@]12C[C@H](CN1C([C@@H](NC([C@@]3(CCCCN3C([C@@]4(CCCN4C([C@H]([C@@H](OC2=O)C)NC([C@@H](NC(/C=C/C=C/CCC)=O)CC5=CC(F)=CC(F)=C5)=O)=O)[H])=O)[H])=O)C)=O)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.