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Ageladine A dihydrochloride

MMP Inhibitor

Ageladine A dihydrochloride is a potent matrix metalloproteinase (MMP) inhibitor derived from the marine sponge Agelas nakamurai, exhibiting anti-angiogenic properties. It effectively targets multiple MMPs, including MMP-1, MMP-2, MMP-8, MMP-9, MMP-12, and MMP-13, with varying IC50 values indicating strong inhibitory effects. Additionally, Ageladine A dihydrochloride functions as a pH-sensitive, membrane-permeable fluorescent dye, emitting blue-green fluorescence upon UV excitation, making it a valuable tool for monitoring intracellular pH changes in biological research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2757574-06-2
Applications	MMP Inhibitor
Formula	C₁₀H₉Br₂Cl₂N₅
Molecular Weight	429.93
SMILES	BrC1=C(Br)NC(C2=NC=CC3=C2N=C(N)N3)=C1.Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.