Ald-CH2-PEG5-azide is a non-cleavable linker consisting of a five-unit polyethylene glycol (PEG) chain, specifically designed for use in antibody-drug conjugates (ADCs). This compound incorporates an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules and those containing DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for the efficient synthesis of ADCs, facilitating targeted drug delivery in research applications.
Ald-CH2-PEG5-azide is a non-cleavable linker consisting of a five-unit polyethylene glycol (PEG) chain, specifically designed for use in antibody-drug conjugates (ADCs). This compound incorporates an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules and those containing DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for the efficient synthesis of ADCs, facilitating targeted drug delivery in research applications.
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