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Amyloid b-Peptide (1-42) (human)

Catalog No.: A14075

Amyloid b-Peptide (1-42) (human)

Amyloid b-Peptide (1-42) (human) Chemical Structure

CAS NO. 107761-42-2

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

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1 mg
$150.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Seda Onder, .et al. Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer's disease, Chem Biol Interact, 2022, Aug 25;363:110029 PMID: 35779611
  • Seham S El-Hawary, .et al. Anti-Alzheimer chemical constituents of Morus macroura Miq.: chemical profiling, in silico and in vitro investigations, Food Funct, 2022, Sep 7;12(17):8078-8089 PMID: 34286787
  • Zsolt Datki, .et al. The interacting rotifer-biopolymers are anti- and disaggregating agents for human-type beta-amyloid in vitro, Int J Biol Macromol, 2022, Jan 7;201:262-269 PMID: 34999044
  • Suresh K.Bowroju, .et al. Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer??s disease, Bioorg Med Chem, 2021, 45:116311
  • Zsolt Datki, .et al. Exogenic production of bioactive filamentous biopolymer by monogonant rotifers, Ecotoxicol Environ Saf, 2021, Jan 15;208:111666 PMID: 33396176

Biological Activity

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 2.22 mL 11.08 mL 22.15 mL
0.5 mM 0.44 mL 2.22 mL 4.43 mL
1 mM 0.22 mL 1.11 mL 2.22 mL
5 mM 0.04 mL 0.22 mL 0.44 mL

*The above data is based on the productmolecular weight 4514.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14075
CAS No. 107761-42-2
Formula C203H311N55O60S
M. Wt 4514.08
Purity >98%
SMILES [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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