Antibacterial agent 199 is an activator of caseinolytic protease (ClpP) with a dissociation constant (Kd) of 0.7 μM. This compound demonstrates significant antibacterial activity against Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae, as well as the Gram-negative bacterium Neisseria meningitidis, with minimum inhibitory concentrations (MICs) of 16 μg/mL, 0.5 μg/mL, and 0.5 μg/mL, respectively. Antibacterial agent 199 is suitable for studies focused on bacterial resistance and the development of novel antimicrobial therapies.
Antibacterial agent 199 is an activator of caseinolytic protease (ClpP) with a dissociation constant (Kd) of 0.7 μM. This compound demonstrates significant antibacterial activity against Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae, as well as the Gram-negative bacterium Neisseria meningitidis, with minimum inhibitory concentrations (MICs) of 16 μg/mL, 0.5 μg/mL, and 0.5 μg/mL, respectively. Antibacterial agent 199 is suitable for studies focused on bacterial resistance and the development of novel antimicrobial therapies.
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