Antibacterial agent 258 (Compound 11e) disrupts bacterial cell membranes, demonstrating potent antibacterial activity against various Gram-positive bacteria, with a minimum inhibitory concentration (MIC) of 1-2 μg/mL for Staphylococcus aureus. The compound exhibits low hemolytic activity and minimal cytotoxicity, making it a promising candidate for therapeutic applications. Additionally, antibacterial agent 258 shows effective anti-infectious efficacy in mouse models, supporting its potential for further research in infection control.
Antibacterial agent 258 (Compound 11e) disrupts bacterial cell membranes, demonstrating potent antibacterial activity against various Gram-positive bacteria, with a minimum inhibitory concentration (MIC) of 1-2 μg/mL for Staphylococcus aureus. The compound exhibits low hemolytic activity and minimal cytotoxicity, making it a promising candidate for therapeutic applications. Additionally, antibacterial agent 258 shows effective anti-infectious efficacy in mouse models, supporting its potential for further research in infection control.
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