Antileishmanial agent-13 is a quinoline-isatin hybrid that functions as an effective antileishmanial agent targeting the L. major strain of Leishmania. This compound exerts its activity through an anti-folate mechanism, demonstrating potent inhibition against both promastigote and amastigote forms, with IC50 values of 0.604 μM and 0.508 μM, respectively. Its significant biological activity makes it a valuable reagent for research in Leishmaniasis treatment and drug development.
Antileishmanial agent-13 is a quinoline-isatin hybrid that functions as an effective antileishmanial agent targeting the L. major strain of Leishmania. This compound exerts its activity through an anti-folate mechanism, demonstrating potent inhibition against both promastigote and amastigote forms, with IC50 values of 0.604 μM and 0.508 μM, respectively. Its significant biological activity makes it a valuable reagent for research in Leishmaniasis treatment and drug development.
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