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Antimicrobial agent-34

Bacteria Inhibitor

Antimicrobial agent-34 (compound 4h) is a potent antibacterial agent targeting bacterial cell membranes, with a minimum inhibitory concentration (MIC) of 1–4 μg/mL. This compound exhibits noteworthy plasma stability (HC50 of 131.1 μg/mL) and favorable membrane selectivity, characterized by an HC50/MIC ratio of 65.6. Antimicrobial agent-34's mechanism of action involves compromising the integrity of bacterial membranes, leading to increased intracellular reactive oxygen species and subsequent leakage of protein and DNA, culminating in bacterial cell death. Its significant in vivo activity is demonstrated in a mouse sepsis model infected with Staphylococcus aureus ATCC43300, making it a valuable tool for antibacterial research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3055131-42-2
Applications	Bacteria Inhibitor
Formula	C₃₂H₅₂N₂O₃
Molecular Weight	512.77
SMILES	CC(C=C1)(CC/C=C(C)\C)OC2=C1C(OCCCNCCCN(CCCC)CCCC)=C(C(C)=O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.