Fig. 1 · Structure
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Antitubercular agent-31
DprE1 Inhibitor
Antitubercular agent-31 is a potent DprE1 inhibitor demonstrated to possess a minimum inhibitory concentration (MIC) of 0.03 μM against Mycobacterium tuberculosis H37Rv. With an IC50 value of 1.1 μM, this compound effectively disrupts the enzymatic activity of DprE1, making it a valuable tool for research in tuberculosis biology and drug discovery. It offers potential for further exploration in the development of new antitubercular therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2764818-29-1 |
| Applications | DprE1 Inhibitor |
| Formula | C20H24F2N4O5S2 |
| Molecular Weight | 502.56 |
| SMILES | O=C1N=C(N2CCN(CC3CCC(F)(F)CC3)CC2)SC4=C([N+]([O-])=O)C=C(S(=O)(C)=O)C=C14 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.