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Apoptosis Inducers

Apoptosis inducers are compounds that trigger programmed cell death through mitochondrial, caspase or stress pathways. Apoptosis is a regulated form of cell death marked by caspase activation, chromatin condensation and cell shrinkage. Inducers serve to study how cells commit to death and as positive controls in cell death assays. Tasisulam, an acylsulfonamide, is described as acting through the intrinsic mitochondrial pathway with caspase activation. Homoharringtonine, a Cephalotaxus alkaloid, inhibits protein synthesis and lowers signal transducer and activator of transcription 3 (STAT3) signaling. Episilvestrol, a rocaglate from Aglaia plants, targets eukaryotic initiation factor 4A (eIF4A). Compounds acting on one defined apoptosis regulator are listed in sibling categories such as Bcl-2 Family and Caspase.

2 Items

  • Autophagy inducer 7
    Cat. No.
    A25876
    CAS No.
    944159-20-0

    Autophagy inducer 7

    Autophagy Inducer 7 is an effective modulator of autophagy and apoptosis, primarily targeting the Akt/mTOR signaling pathway. This compound promotes autophagy by inhibiting pathway activity and downregulating associated proteins, leading to a reduction in DNA synthesis and inducing G0-G1 cell cycle arrest. Additionally, Autophagy Inducer 7 has demonstrated the ability to inhibit tumor cell proliferation, making it a valuable tool for research in cancer biology and therapeutic strategies involving autophagy.

    In stock View Details
    1 mg
    $70.00
    5 mg
    $140.00
    All 6 sizes
  • Safrole oxide
    Cat. No.
    A53889
    CAS No.
    7470-44-2

    Safrole oxide

    Safrole oxide is a p53 modulator that enhances the expression of the p53 tumor suppressor protein, facilitating cell cycle arrest and promoting apoptosis. This compound effectively induces apoptosis in lung cancer cells while avoiding necrotic cell death. Safrole oxide is valuable for research focused on lung cancer mechanisms and therapeutic strategies.

    In stock View Details
    1 mg
    $235.00
    5 mg
    $590.00
    All 6 sizes

2 Items

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