Glutathione Peroxidase

Cat. No.

A27033

CAS No.

128700-97-0

Gingerenone A

Gingerenone A is an Nrf2-Gpx4 activator that triggers ferroptosis in liver tissue, demonstrating significant potential for therapeutic intervention in liver damage. This compound exhibits notable anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging properties observed in murine models, making it valuable for research in oxidative stress regulation and associated diseases. Its oral bioactivity further enhances its applicability in in vivo studies.

Cat. No.

A27076

CAS No.

950365-31-8

GPX4 activator 2

GPX4 Activator 2 is a potent activator of glutathione peroxidase 4 (GPX4), a key enzyme involved in reducing oxidative stress. It demonstrates significant cardioprotective effects and effectively inhibits cellular ferroptosis with an EC50 of 7.8 μM. This compound is valuable for research applications focused on myocardial injury and the mechanisms of ferroptosis in cardiovascular diseases.

Cat. No.

A53735

CAS No.

2143896-83-5

PKUMDL-LC-101-D04

Synonyms: GPX4-Activator-1d4

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4), exhibiting a pEC50 value of 4.7. This compound effectively inhibits ferroptosis and reduces inflammatory responses, making it a valuable tool for research investigating oxidative stress and related pathologies. Its ability to modulate GPX4 activity highlights its potential applications in studies focused on cell survival and neuroprotection.

Cat. No.

A53761

CAS No.

3036889-54-7

DEL-I25

DEL-I25 is a potent activator of glutathione peroxidase 4 (GPX4), a critical enzyme involved in cellular antioxidant defense. This compound effectively protects cells from ferroptosis, a form of regulated cell death associated with oxidative stress. DEL-I25 is valuable in research applications focused on understanding ferroptosis mechanisms and developing therapeutic strategies for diseases related to oxidative damage.

Cat. No.

A53767

CAS No.

2584411-86-7

RC363

RC363 is a novel glutathione peroxidase (GPx) activator designed to enhance the levels and activity of GPx1. This compound demonstrates protective effects on mouse hippocampal cells and primary cortical neurons against glutamate-induced oxidative cell death, specifically ferroptosis. RC363 is valuable for research investigating oxidative stress and neuroprotection mechanisms.