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MDM2

MDM2 inhibitors disrupt the binding of mouse double minute 2 homolog (MDM2) to the tumor suppressor p53. In 1992 the MDM2 protein was shown to form a complex with p53 and inhibit p53-mediated transactivation. MDM2 is also an E3 ubiquitin ligase that promotes the rapid degradation of p53, as reported in 1997. Nutlins, reported in 2004, occupy the p53-binding pocket of MDM2 and activate the p53 pathway in cells and in vivo. Nutlin 3a is the active enantiomer of nutlin-3, and Nutlin 3b is a much weaker enantiomer used as a control. RG7112 and APG-115 are further MDM2 inhibitors, while MD-224 is a degrader that removes MDM2 protein. SJ 172550 targets the MDM2 relative MDM4 (also called MDMX).

3 Items

  • Nutlin-3
    Cat. No.
    A10657
    CAS No.
    548472-68-0

    Nutlin-3

    MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

    In stock View Details
    2 mg
    $45.00
    5 mg
    $60.00
    All 7 sizes
  • Kevetrin HCl
    Cat. No.
    A13797
    CAS No.
    66592-89-0

    Kevetrin HCl

    Synonyms: thioureidobutyronitrile

    Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.

    In stock View Details
    5 mg
    $30.00
    10 mg
    $55.00
    All 7 sizes
  • WR 1065
    Cat. No.
    A15353
    CAS No.
    14653-77-1

    WR 1065

    WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure.

    In stock View Details
    5 mg
    $25.00
    10 mg
    $35.00
    All 5 sizes

3 Items

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