RIP Kinase | Adooq Bioscience

Cat. No.: A25071

CAS No.: 2361988-77-2

cRIPGBM chloride

cRIPGBM chloride is a selective modulator of receptor-interacting protein kinase 2 (RIPK2) that induces caspase 1-dependent apoptosis. This compound effectively disrupts the RIPK2/TAK1 prosurvival complex while promoting the formation of the RIPK2/caspase 1 pro-apoptotic complex. cRIPGBM chloride demonstrates significant anti-tumor efficacy in vivo in animal models, making it a valuable tool for research into glioblastoma multiforme (GBM) and related cancer therapies. Its proapoptotic properties offer insights into mechanisms of cell death and potential therapeutic strategies in cancer treatment.

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$25.00

5 mg

$50.00

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Cat. No.: A25230

CAS No.: 1456899-52-7

RIP3 activator 1

RIP3 Activator 1 is a potent activator of receptor-interacting protein kinase 3 (RIP3). This compound induces necroptosis by engaging the RIP3/p62/Keap1 signaling pathway and promotes the expression of phosphorylated mixed lineage kinase domain-like protein (p-MLKL). Additionally, RIP3 Activator 1 enhances autophagy, evidenced by increased levels of LC3-II and p62 protein expression. It serves as a valuable tool for studying signaling pathways related to necroptosis and autophagy in various cellular contexts.

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Cat. No.: A25235

CAS No.: 2857845-45-3

RIPK1-IN-31

RIPK1-IN-31 is a selective allosteric modulator of receptor-interacting protein kinase 1 (RIPK1) with an IC50 value of 16 nM. This compound demonstrates potential for modulating RIPK1 activity, making it a valuable tool for research in the fields of infectious, autoimmune, and neurodegenerative diseases. Its ability to selectively influence RIPK1 pathways can aid in elucidating the mechanisms underlying these conditions.

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