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Survivin

Survivin inhibitors and suppressants act on the smallest member of the inhibitor of apoptosis (IAP) protein family. Survivin, the product of the baculoviral IAP repeat-containing 5 (BIRC5) gene, was described in 1997 as an anti-apoptosis protein expressed in cancer and lymphoma. Survivin also belongs to the chromosomal passenger complex, which controls chromosome segregation and cytokinesis during mitosis. Sepantronium bromide (YM155) was reported in 2007 as a small-molecule suppressant of survivin expression. FL118 and its enantiomer (R)-FL118 are camptothecin analogs that also lower survivin expression. LQZ-7F interferes with survivin dimerization, and shepherdin (79-87) is a peptide that blocks survivin binding to heat shock protein 90 (HSP90). Compounds for other inhibitor of apoptosis proteins are listed under IAP.

2 Items

  • UC-112
    Cat. No.
    A30781
    CAS No.
    383392-66-3

    UC-112

    UC-112 is a selective modulator of survivin and XIAP, with notable anticancer properties. It induces the degradation of survivin through the ubiquitin-mediated proteasomal pathway, while also decreasing XIAP levels in in vivo tumor models. This compound activates caspase-3/7 and caspase-9, promoting apoptosis in cancer cells. UC-112 is relevant for research into melanoma, prostate cancer, and various cancer-related studies.

    In stock View Details
    1 mg
    $25.00
    2 mg
    $30.00
    All 7 sizes
  • Shepherdin (79-87)
    Cat. No.
    A37528
    CAS No.
    861224-28-4

    Shepherdin (79-87)

    Shepherdin (79-87) is a peptidomimetic antagonist targeting the interaction between Heat Shock Protein 90 (Hsp90) and Survivin. This fragment, representing amino acids 79 to 87 of the full Shepherdin sequence, demonstrates significant anticancer activity by disrupting the chaperone function of Hsp90, leading to the destabilization of Survivin. It is primarily utilized in cancer research to explore mechanisms of apoptosis and investigate therapeutic strategies targeting cell survival pathways.

    In stock View Details
    25 mg
    $1,275.00
    All 1 sizes

2 Items

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