We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

TNF-α

Tumor necrosis factor alpha (TNF-α) inhibitors reduce the production or signaling of a central inflammatory cytokine. In 1975 an endotoxin-induced serum factor that causes necrosis of tumors was described and named tumor necrosis factor. Cloning of human TNF in 1984 revealed a precursor related to lymphotoxin. Through its two receptors, TNF-α activates nuclear factor kappa B (NF-κB) and cell death pathways. Etanercept is a soluble receptor fusion protein that binds the cytokine, and C 87 is a small-molecule TNF-α inhibitor. In 1991 thalidomide was shown to inhibit TNF-α production by stimulated human monocytes, and its analogs lenalidomide and pomalidomide are also listed. Pathway compounds include the NF-κB inhibitor QNZ and necrostatin-1, an inhibitor of receptor-interacting protein kinase 1 (RIPK1).

3 Items

  • IDT
    Cat. No.
    A25512
    CAS No.
    18138-19-7

    IDT

    IDT is a TNFα modulator that targets and regulates the innate immune response. It has demonstrated significant efficacy in reducing paired helical filament tau and fibrillar amyloid accumulation, as well as enhancing the infiltration of neutrophils while decreasing TNFα expression within this population. IDT is a valuable reagent for research focused on Alzheimer’s disease and the underlying mechanisms of neuroinflammation.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • D-Trimannuronic acid
    Cat. No.
    A25553
    CAS No.
    66754-13-0

    D-Trimannuronic acid

    D-Trimannuronic acid, a TNF receptor activator derived from alginate oligomers in seaweed, stimulates the secretion of TNF-α in mouse macrophage cell lines. This compound is valuable in research focused on inflammatory responses, pain mechanisms, and vascular dementia. Its unique biological activity provides insights into immune modulation and related therapeutic areas.

    In stock View Details
    5 mg
    $190.00
    All 1 sizes
  • LY 303511 hydrochloride
    Cat. No.
    A26200
    CAS No.
    2070014-90-1

    LY 303511 hydrochloride

    LY 303511 hydrochloride is a structural analogue of LY294002 and acts as a TNF receptor activator. It enhances the sensitivity of SHEP-1 neuroblastoma cells to TRAIL, making it a valuable tool for investigating apoptosis mechanisms in cancer research. Additionally, LY 303511 reversibly blocks potassium currents in MIN6 insulinoma cells with an IC50 value of 64.6 ± 9.1 μM, facilitating studies in insulin secretion and pancreatic function.

    In stock View Details
    1 mg
    $25.00
    5 mg
    $60.00
    All 6 sizes

3 Items

Added to your cart

View Cart Checkout

    Loading...