Apremilast-d8 is a deuterium-labeled derivative of Apremilast, an orally active inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with a reported IC50 of 74 nM. This reagent effectively inhibits the release of tumor necrosis factor-alpha (TNF-α) induced by lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. Apremilast-d8 is ideal for stable isotope labeling applications in biochemical and pharmacological research, particularly in studies examining PDE-4 inhibition and its effects on inflammatory pathways.
Apremilast-d8 is a deuterium-labeled derivative of Apremilast, an orally active inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with a reported IC50 of 74 nM. This reagent effectively inhibits the release of tumor necrosis factor-alpha (TNF-α) induced by lipopolysaccharide (LPS), exhibiting an IC50 of 104 nM. Apremilast-d8 is ideal for stable isotope labeling applications in biochemical and pharmacological research, particularly in studies examining PDE-4 inhibition and its effects on inflammatory pathways.
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