Fig. 1 · Structure
Documents & Downloads
Avatrombopag hydrochloride
TPO Receptor Agonist
Avatrombopag hydrochloride is a nonpeptide thrombopoietin (TPO) receptor agonist with an EC50 of 3.3 nM. It effectively mimics the biological actions of TPO, leading to enhanced platelet production by activating intracellular signaling pathways and promoting the differentiation of megakaryocytes and platelets from hematopoietic precursor cells. This compound serves as a valuable tool for research focused on disorders of thrombocytopenia and related hematological studies. Avatrombopag hydrochloride is also metabolized by cytochrome P450 enzymes CYP2C9 and CYP3A.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 570403-17-7 |
| Applications | TPO Receptor Agonist |
| Formula | C29H35Cl3N6O3S2 |
| Molecular Weight | 686.12 |
| Synonyms | AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride |
| SMILES | O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.