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Avicin G

Catalog No.: A63772
Sphingomyelinase Inhibitor, K-Ras Inhibitor, H-Ras Inhibitor, NF-κB Inhibitor
Avicin G is a potent inhibitor of sphingomyelinases, specifically targeting neutral sphingomyelinases (SMPD2/3) and acid sphingomyelinase (SMPD1). This compound elevates intracellular sphingomyelin levels and modulates the distribution of sphingomyelin, disrupting signal transduction pathways in oncogenic K-Ras and H-Ras. Avicin G exhibits significant biological activity, including the reduction of ERK and Akt phosphorylation and alterations in lysosomal pH. Its applications extend to research on pancreatic ductal adenocarcinoma and non-small cell lung cancer.
Avicin G 197787-17-0 Sphingomyelinase Inhibitor, K-Ras Inhibitor, H-Ras Inhibitor, NF-κB Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAvicin G is a potent inhibitor of sphingomyelinases, specifically targeting neutral sphingomyelinases (SMPD2/3) and acid sphingomyelinase (SMPD1). This compound elevates intracellular sphingomyelin levels and modulates the distribution of sphingomyelin, disrupting signal transduction pathways in oncogenic K-Ras and H-Ras. Avicin G exhibits significant biological activity, including the reduction of ERK and Akt phosphorylation and alterations in lysosomal pH. Its applications extend to research on pancreatic ductal adenocarcinoma and non-small cell lung cancer.
Product Information
Catalog NumA63772
FormulaC98H155NO45
Molecular Weight2067.26
CAS Number197787-17-0
SMILESC=C[C@@](O)(C)CC/C=C(C)/C(O[C@@H]([C@H](O)[C@H]1O)[C@@H](C)O[C@H]1O[C@@](C)(C=C)CC/C=C(CO)/C(O[C@H]2C[C@]3(C(O[C@H]4[C@H](O[C@@H]5O[C@@H](C)[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](CO)O6)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O)[C@H](O)C[C@@]8(C)[C@]9(C)CC[C@@]%10([H])C(C)(C)[C@@H](O[C@H]%11[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]%12O[C@H](C)[C@H](O)[C@H](O)[C@H]%12O[C@@H]%13OC[C@@H](O)[C@H](O)[C@H]%13O)O%11)NC(C)=O)CC[C@]%10(C)[C@@]9([H])CC=C8[C@]3([H])CC2(C)C)=O)=O
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NF-κB/IκB > NF-κB