Basivarsen linker is an innovative linker designed for antibody-drug conjugates (ADCs). It facilitates the coupling of a transferrin receptor 1 (TfR1) binding Fab and an antisense oligonucleotide, forming the basis of the antibody-oligonucleotide conjugate (AOC) Zeleciment basivarsen. This conjugate specifically targets mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA, promoting its degradation through RHase H and aiming to correct splicing abnormalities. Basivarsen linker is essential for research into myotonic dystrophy type 1 (DM1) and its therapeutic approaches.
Basivarsen linker is an innovative linker designed for antibody-drug conjugates (ADCs). It facilitates the coupling of a transferrin receptor 1 (TfR1) binding Fab and an antisense oligonucleotide, forming the basis of the antibody-oligonucleotide conjugate (AOC) Zeleciment basivarsen. This conjugate specifically targets mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA, promoting its degradation through RHase H and aiming to correct splicing abnormalities. Basivarsen linker is essential for research into myotonic dystrophy type 1 (DM1) and its therapeutic approaches.
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