Fig. 1 · Structure
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Benpyrine
TNF-α Inhibitor
Benpyrine is a selective TNF-α inhibitor that effectively disrupts the interaction between TNF-α and its receptor TNFR1, demonstrating an IC50 value of 0.109 µM. With a KD value of 82.1 μM, this orally active compound is suitable for exploring the mechanisms involved in TNF-α mediated inflammatory and autoimmune diseases. Benpyrine is a valuable tool for research applications focused on chronic inflammation and therapeutic modulation of immune responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2550398-89-3 |
| Applications | TNF-α Inhibitor |
| Formula | C16H16N6O |
| Molecular Weight | 308.34 |
| SMILES | O=C(N(CC1=CC=CC=C1)C2)C[C@@H]2NC3=C4C(NC=N4)=NC=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.