Fig. 1 · Structure
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(R)-Benpyrine
Isomer
(R)-Benpyrine is the isomeric form of Benpyrine, serving as a critical experimental control in research. This compound acts as a highly specific, orally active inhibitor of TNF-α, demonstrating a KD value of 82.1 μM. It exhibits strong binding to TNF-α, effectively blocking its interaction with TNFR1, as indicated by an IC50 value of 0.109 μM. (R)-Benpyrine is suitable for investigations into TNF-α-mediated inflammatory and autoimmune diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2637243-08-2 |
| Applications | Isomer |
| Formula | C16H16N6O |
| Molecular Weight | 308.34 |
| SMILES | O=C(N(CC1=CC=CC=C1)C2)C[C@H]2NC3=C4C(NC=N4)=NC=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.