BF-170 is a selective tau fibril binding agent that targets tau protein aggregates, exhibiting an EC50 of 221 nM. It demonstrates effective blood-brain barrier permeability, with brain tissue concentrations reaching 9.1% ID/g within 2 minutes post intravenous administration in mice. BF-170 serves as a valuable tool for imaging tau pathology associated with Alzheimer's disease and is instrumental in early-stage AD research, offering potential for studies focused on tau-related neurodegenerative disorders.
BF-170 is a selective tau fibril binding agent that targets tau protein aggregates, exhibiting an EC50 of 221 nM. It demonstrates effective blood-brain barrier permeability, with brain tissue concentrations reaching 9.1% ID/g within 2 minutes post intravenous administration in mice. BF-170 serves as a valuable tool for imaging tau pathology associated with Alzheimer's disease and is instrumental in early-stage AD research, offering potential for studies focused on tau-related neurodegenerative disorders.
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