- Cat. No.
- A12469
IDE1
IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.
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Stem cell reprogramming and differentiation reagents are small molecules that steer cell identity in culture. Chemical cocktails can replace or support transcription factors when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs). Frequent components include the histone deacetylase (HDAC) inhibitor valproic acid and the lysine-specific demethylase 1 (LSD1) inhibitor tranylcypromine. RepSox blocks the transforming growth factor beta (TGF-β) type I receptor and can replace the transcription factor Sox2. Inhibition of glycogen synthase kinase 3 (GSK-3) with CHIR-99021 and of MAP kinase kinase (MEK) with PD0325901 keeps mouse embryonic stem cells in the ground state. Differentiation protocols use retinoic acid, the Hedgehog pathway agonists SAG and purmorphamine, and IDE1 for definitive endoderm.
IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.
Synonyms: SR-1
StemRegenin 1 (SR1) is a cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs).
Cardiogenol C is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
Synonyms: Isoxazole 9
ISX-9 is a small molecule inducer of adult neural stem cell differentiation.
O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation.
Neurodazine is a neurogenesis inducer that promotes the differentiation of pluripotent cells into neuronal lineages. This compound activates the Wnt and Shh signaling pathways, facilitating neural development and potentially improving neuroregeneration applications. Neurodazine is suitable for research in developmental biology, neuroscience, and regenerative medicine.
Synonyms: SR1 hydrochloride
Stemregenin 1 hydrochloride is a purine derivative that acts as an antagonist of the aryl hydrocarbon receptor (AhR). It has been shown to inhibit AhR signaling in CD34+ cells with an IC50 value of 127 nM. This compound is utilized in stem cell research to enhance the pluripotency and expansion of hematopoietic stem cells (HSC), providing valuable insights into stem cell biology and regenerative medicine.
Oct4 inducer-2 is a compound that promotes the expression of endogenous OCT4, facilitating the maintenance and proliferation of human induced pluripotent stem cells (hiPSCs). This inducer is valuable for research applications focused on stem cell biology, regenerative medicine, and anti-aging studies. By enhancing OCT4 levels, Oct4 inducer-2 supports the maintenance of pluripotency, making it an essential tool for scientists investigating cellular reprogramming and differentiation.
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