Neurology | Adooq Bioscience

Cat. No.: AT0326

CAS No.: 1791416-49-3

Elezanumab

Synonyms: ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab

Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody designed for high selectivity toward repulsive guidance molecule A (RGMa). This antibody effectively inhibits RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, demonstrating a potent inhibitory concentration (IC50) of approximately 97 pM. Elezanumab binds to the N-terminal of RGMa, effectively blocking BMP signaling pathways and demonstrating no cross-reactivity with RGMc. It has been shown to promote both neuroregeneration and neuroprotection across various models of neuronal injury and demyelination. Importantly, Elezanumab exerts its neuroregenerative and neuroprotective effects without affecting iron metabolism, making it a targeted therapeutic option for neurological research and potential clinical applications.

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Cat. No.: AT0719

CAS No.: 1578199-75-3

Galcanezumab

Synonyms: LY 2951742

Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody designed to specifically target and neutralize the calcitonin gene-related peptide (CGRP) ligand. This antibody is utilized extensively in research focused on migraine and cluster headaches, providing a valuable tool for investigating the pathophysiology and potential therapeutic interventions for these conditions.

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Cat. No.: AT1044

CAS No.: 2097151-87-4

Pepinemab

Synonyms: VX 15/2503

Pepinemab (VX 15/2503) is a human monoclonal antibody designed to target and neutralize SEMA4D (Signaling Protein 4D), also recognized as CD100. SEMA4D is a critical regulator of neuronal development and is implicated in a range of cellular processes. By inhibiting the activity of SEMA4D, Pepinemab serves as a valuable tool for the investigation of neurodegenerative disorders, including Alzheimer's disease. This antibody is specifically engineered for research applications focused on elucidating the role of SEMA4D in disease pathogenesis and cellular function.

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Cat. No.: AT1185

CAS No.: 880266-57-9

Tanezumab

Synonyms: RN-624; PF 4383119

Tanezumab (RN-624) is a humanized monoclonal antibody that exhibits high affinity and specificity for nerve growth factor (NGF). By effectively blocking the interaction of NGF with its receptors, p75 and TrkA, Tanezumab modulates pain signaling pathways in the peripheral nervous system. This antibody is utilized extensively in research focused on both acute and chronic pain conditions, including osteoarthritis, knee pain, neuralgia, and post-herpetic neuralgia, providing a valuable tool for the study of pain mechanisms and therapeutic interventions.

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