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Co-stimulatory Receptors

Co-stimulatory receptor antibodies activate T cells or antigen-presenting cells through OX40, 4-1BB, CD40 and CD27. Most of these receptors belong to the tumor necrosis factor receptor superfamily (TNFRSF) and signal after clustering, so antibody format and Fc receptor binding shape activity. Urelumab and utomilumab are agonists of 4-1BB (CD137), and varlilumab targets CD27 on lymphocytes. Selicrelumab activates CD40 on dendritic cells and B cells, supporting antigen presentation in immune-priming models. Antibodies to glucocorticoid-induced TNFR-related protein (GITR), inducible T-cell co-stimulator (ICOS) and CD28 complete the group.

5 Items

  • Lulizumab — antibody illustration
    Cat. No.
    AT0874
    CAS No.
    2235419-62-0

    Lulizumab

    Synonyms: Humanized Anti-CD28 Recombinant Antibody

    Lulizumab is a humanized recombinant antibody that acts as an antagonist to the CD28 domain. This antibody selectively targets the CD28 signal, effectively inhibiting T-cell activation. In research studies, specifically using a sensitized non-human primate kidney transplantation model, Lulizumab has demonstrated the ability to modulate immune cell responses. When used in combination with Carfilzomib, it has shown potential in prolonging graft survival times, indicating its utility in transplant immunology and immune regulation studies.

    In stock View Details
    1 mg
    $280.00
    5 mg
    $728.00
    All 3 sizes
  • Lucatumumab — antibody illustration
    Cat. No.
    AT0981
    CAS No.
    903512-50-5

    Lucatumumab

    Synonyms: HCD122

    Lucatumumab (HCD122) is a fully human monoclonal antibody that functions as an antagonist to CD40, effectively blocking CD40/CD40L-mediated signaling pathways. This antibody is proficient in mediating antibody-dependent cell-mediated cytotoxicity (ADCC), facilitating the clearance of tumor cells. It is primarily utilized in research focused on refractory lymphomas, chronic lymphocytic leukemia (CLL), and multiple myeloma, offering significant insights into therapeutic strategies for these malignancies.

    In stock View Details
    1 mg
    $200.00
    5 mg
    $544.00
    All 3 sizes
  • Bleselumab — antibody illustration
    Cat. No.
    AT1372
    CAS No.
    1453067-91-8

    Bleselumab

    Synonyms: ASKP 1240

    Bleselumab (ASKP 1240) is a humanized monoclonal antibody targeting CD40 with a high affinity of approximately 0.24 nM. By selectively binding to CD40, Bleselumab effectively blocks the interaction between CD40 and its ligand CD40L, a crucial pathway in immune response modulation. This inhibition is particularly relevant in preventing organ transplant rejection, making Bleselumab a significant tool in transplant immunology research.

    In stock View Details
    1 mg
    $240.00
    5 mg
    $624.00
    All 3 sizes
  • Ravagalimab — antibody illustration
    Cat. No.
    AT1380
    CAS No.
    2050816-56-1

    Ravagalimab

    Synonyms: ABBV-323

    Ravagalimab (ABBV-323) functions as a potent CD40 antagonist with an EC50 value of 3.7 nM. This monoclonal antibody is primarily utilized in the research of Crohn's disease, offering a valuable tool for investigating the pathophysiology and potential therapeutic interventions targeting the CD40 pathway in this condition.

    In stock View Details
    1 mg
    $320.00
    5 mg
    $960.00
    All 3 sizes
  • Teneliximab — antibody illustration
    Cat. No.
    AT1511
    CAS No.
    299423-37-3

    Teneliximab

    Synonyms: BMS 224819; Chi220; Anti-Human CD40 Recombinant Antibody

    Teneliximab (BMS-224819) is a chimeric monoclonal antibody designed to inhibit the interaction between CD40 and CD40L. This antibody exhibits partial agonist activity, enabling limited signaling through CD40. Additionally, Teneliximab facilitates the depletion of peripheral B cells, making it a valuable tool for research into immune system modulation and potential therapeutic applications targeting B cell-mediated disorders.

    In stock View Details
    1 mg
    $200.00
    5 mg
    $520.00
    All 3 sizes

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