Biotin-PEG1-azide is a cleavable PEG-based linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide functional group, allowing for efficient coupling through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-PEG1-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when interacting with DBCO or BCN moieties, facilitating versatile labeling and conjugation strategies in chemical biology and therapeutic applications.
Biotin-PEG1-azide is a cleavable PEG-based linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide functional group, allowing for efficient coupling through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-PEG1-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when interacting with DBCO or BCN moieties, facilitating versatile labeling and conjugation strategies in chemical biology and therapeutic applications.
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