BMS-818251 is a highly potent small-molecule inhibitor that targets HIV-1 entry, exhibiting an EC50 value of 0.019 nM. Its superior efficacy is demonstrated by over 10-fold increased potency compared to related compounds across a diverse panel of 208 HIV-1 strains. BMS-818251 enhances its inhibitory effects by interacting with conserved gp120 residues, specifically the β20-β21 hairpin, making it a valuable tool for research in HIV resistance and therapeutics.
BMS-818251 is a highly potent small-molecule inhibitor that targets HIV-1 entry, exhibiting an EC50 value of 0.019 nM. Its superior efficacy is demonstrated by over 10-fold increased potency compared to related compounds across a diverse panel of 208 HIV-1 strains. BMS-818251 enhances its inhibitory effects by interacting with conserved gp120 residues, specifically the β20-β21 hairpin, making it a valuable tool for research in HIV resistance and therapeutics.
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