TAT-PiET-PROTAC is a BRD4 inhibitor designed as a proteolysis-targeting chimera (PROTAC) that incorporates the cell-penetrating peptide TAT-PiET. This compound effectively reduces the levels of BRD4 and JMJD6, demonstrating significant inhibition of cell proliferation. TAT-PiET-PROTAC is particularly relevant for investigating endocrine resistance in ERα-positive breast cancer cells, making it a valuable tool for cancer research.
TAT-PiET-PROTAC is a BRD4 inhibitor designed as a proteolysis-targeting chimera (PROTAC) that incorporates the cell-penetrating peptide TAT-PiET. This compound effectively reduces the levels of BRD4 and JMJD6, demonstrating significant inhibition of cell proliferation. TAT-PiET-PROTAC is particularly relevant for investigating endocrine resistance in ERα-positive breast cancer cells, making it a valuable tool for cancer research.
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