Fig. 1 · Structure
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BS-181 dihydrochloride
CDK7 Inhibitor
BS-181 dihydrochloride is a highly selective inhibitor of cyclin-dependent kinase 7 (CDK7) with an IC50 of 21 nM, showcasing superior potency compared to alternative compounds. It also exhibits moderate inhibition against CDK2, CDK5, and CDK9, with IC50 values of 880 nM, 3000 nM, and 4200 nM, respectively. BS-181 dihydrochloride has demonstrated the ability to inhibit the growth of various cancer cell lines (IC50 range of 11.5 μM to 37.3 μM) and to induce apoptosis. This compound is valuable for research applications focused on cancer therapies targeting CDK pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1883548-83-1 |
| Applications | CDK7 Inhibitor |
| Formula | C22H34Cl2N6 |
| Molecular Weight | 453.45 |
| SMILES | CC(C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN)C.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.