Carfilzomib-d8 is a deuterium-labeled derivative of Carfilzomib, an irreversible proteasome inhibitor that exhibits potent activity with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cell lines. This stable isotope can be utilized in pharmacokinetic studies and for tracking drug metabolism and distribution in biological systems. Carfilzomib-d8 serves as a valuable tool for researchers investigating proteasome inhibition and its therapeutic implications in cancer research.
Carfilzomib-d8 is a deuterium-labeled derivative of Carfilzomib, an irreversible proteasome inhibitor that exhibits potent activity with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cell lines. This stable isotope can be utilized in pharmacokinetic studies and for tracking drug metabolism and distribution in biological systems. Carfilzomib-d8 serves as a valuable tool for researchers investigating proteasome inhibition and its therapeutic implications in cancer research.
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