Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Ori Kalid, .et al. PTX80, A Novel Compound Targeting the Autophagy Receptor p62/SQSTM1 for Treatment of Cancer, Chem Biol Drug Des, 2022, Mar 24 PMID: 35322538
- Abbas Rahdar, .et al. Pluronic F127/carfilzomib-based nanomicelles as promising nanocarriers: synthesis, characterization, biological, and in silico evaluations, Journal of Molecular Liquids, 2022, 346: 118271
- Sadegh Zarei, .et al. Carfilzomib Induces Drug Resistance in A2780 Ovarian Cancer Cells Through p53-Dependent and Caspase-3 Independent Pathways, J Appl Biotechnol Rep, 2019, June;6(2):45-49
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Biological Activity
PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
Targets
| Proteasome (ANBL-6 cells) | ||||
| 5 nM |
| In vitro (25°C) | DMSO | 46 mg/mL (63.89 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+2%Tween 80+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.89 mL | 69.45 mL | 138.91 mL |
| 0.5 mM | 2.78 mL | 13.89 mL | 27.78 mL |
| 1 mM | 1.39 mL | 6.95 mL | 13.89 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
*The above data is based on the productmolecular weight 719.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11278 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 868540-17-4 |
| Formula | C40H57N5O7 |
| M. Wt | 719.9 |
| Purity | >98% |
| Synonyms | PR-171-007 |
| SMILES | CC(C)C[[email protected]@H](C(=O)[[email protected]]1(CO1)C)NC(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy PR-171 (Carfilzomib) | PR-171 (Carfilzomib) Supplier | purchase | cost | manufacturer | order | distributor | buy 868540-17-4| 868540-17-4 Supplier | purchase 868540-17-4 | 868540-17-4 cost | 868540-17-4 manufacturer | order 868540-17-4 | 868540-17-4 distributor
Adooq Quality Guarantee
We promise all products perform as described.