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PR-171 (Carfilzomib)

Catalog No.: A11278

Proteasome inhibitor

PR-171 (Carfilzomib)

PR-171 (Carfilzomib) Chemical Structure

CAS NO. 868540-17-4

PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Ori Kalid, .et al. PTX80, A Novel Compound Targeting the Autophagy Receptor p62/SQSTM1 for Treatment of Cancer, Chem Biol Drug Des, 2022, Mar 24 PMID: 35322538
  • Abbas Rahdar, .et al. Pluronic F127/carfilzomib-based nanomicelles as promising nanocarriers: synthesis, characterization, biological, and in silico evaluations, Journal of Molecular Liquids, 2022, 346: 118271
  • Sadegh Zarei, .et al. Carfilzomib Induces Drug Resistance in A2780 Ovarian Cancer Cells Through p53-Dependent and Caspase-3 Independent Pathways, J Appl Biotechnol Rep, 2019, June;6(2):45-49
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
Proteasome (ANBL-6 cells)
5 nM
In vitro (25°C) DMSO 46 mg/mL (63.89 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2%Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.89 mL 69.45 mL 138.91 mL
0.5 mM 2.78 mL 13.89 mL 27.78 mL
1 mM 1.39 mL 6.95 mL 13.89 mL
5 mM 0.28 mL 1.39 mL 2.78 mL

*The above data is based on the productmolecular weight 719.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11278
Actions Inhibitor
CAS No. 868540-17-4
Formula C40H57N5O7
M. Wt 719.9
Purity >98%
Synonyms PR-171-007
SMILES CC(C)C[[email protected]@H](C(=O)[[email protected]]1(CO1)C)NC(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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