CCT128930 hydrochloride is a selective inhibitor of AKT, demonstrating an IC50 of 6 nM. It exhibits significant selectivity, being 28-fold more potent against AKT than the closely related PKA kinase (IC50 of 168 nM) and 20-fold more effective than p70S6K (IC50 of 120 nM). CCT128930 hydrochloride is recognized for its ability to induce cell cycle arrest, promote DNA damage, and stimulate autophagy, enabling its application in cancer research and potential antitumor strategies.
CCT128930 hydrochloride is a selective inhibitor of AKT, demonstrating an IC50 of 6 nM. It exhibits significant selectivity, being 28-fold more potent against AKT than the closely related PKA kinase (IC50 of 168 nM) and 20-fold more effective than p70S6K (IC50 of 120 nM). CCT128930 hydrochloride is recognized for its ability to induce cell cycle arrest, promote DNA damage, and stimulate autophagy, enabling its application in cancer research and potential antitumor strategies.
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