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Ras

Ras inhibitors and related small GTPase modulators act on KRAS and on the Rac, Rho and Cdc42 proteins. Small GTPases of the Ras superfamily work as molecular switches. They cycle between an active form bound to guanosine triphosphate (GTP) and an inactive form bound to guanosine diphosphate (GDP). Oncogenic KRAS mutations such as G12C keep the protein in its signaling state. ARS-853 and KRas G12C inhibitor 4 target the mutant cysteine of KRAS G12C, while Kobe2602 interferes with binding of Ras to Raf. Salirasib, a farnesylcysteine mimetic, disrupts the membrane association of Ras. Rho-family tools include NSC 23766 and EHT 1864, which inhibit Rac, and CASIN, which targets Cdc42.

Items 426-427 of 427

  • 8-Bromo-AMP
    Cat. No.
    A72147
    CAS No.
    23567-96-6

    8-Bromo-AMP

    Synonyms: 8-Bromoadenosine 5'-monophosphate; 8-Bromoadenylic acid

    8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane-permeable analogue of cyclic AMP (cAMP). This compound is primarily involved in cellular signaling pathways, facilitating improvements in ATP and ADP levels, as well as total adenine nucleotide concentrations. Its biological activity is significant in cardiac research, particularly for enhancing heart recovery following ischemia and reperfusion injuries. 8-Bromo-AMP serves as a valuable tool for exploring cAMP-related signaling mechanisms in various physiological and pathological contexts.

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    5 mg
    $205.00
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    $335.00
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  • 2-AHA-cAMP
    Cat. No.
    B11165
    CAS No.
    214276-80-9

    2-AHA-cAMP

    2-AHA-cAMP is a cAMP analogue that acts as an activator of cAMP-dependent protein kinase. The molecule features a free terminal primary amino group, enabling its coupling to gels or fluorescent dyes for enhanced experimental versatility. Its application extends to various research areas including signaling pathways and protein interaction studies, making it a valuable reagent for biophysical and biochemical investigations.

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